Patient Insight
Our Experiences: Past and current studies
| Client | Disease | n= | Method | Year |
|---|---|---|---|---|
| Global CRO | Type II DM | Pilot: 40 Main: 160 | Interview + Web survey | 2015 |
| Global Pharmaceutical Company | NSCLC | Online survey: 160 Interview: 10 | Interview + Web survey | 2016 |
| Japanese Pharmaceutical Company | CNS patients | 1,400 | Phone Interview | 2016 |
| Global CRO | Uterine fibroid | External panel: 200 Seikatsu Kojo panel: 1,616 | Web survey | 2017 |
| Japanese Pharmaceutical Company | Rheumatoid arthritis | MROC: 20 IDI: 5 | MROC + Phone IDI | 2017 |
| Global CRO | Type II DM | Interview: 10 Web survey: 190 | F2F Interview + Web survey | 2018 |
| Global Pharmaceutical Company | Psoriasis | MROC: 50 IDI: 18 | MROC + IDI | On Going |
| Global Pharmaceutical Company | Acne patient survey | MROC: 300 | MROC | On Going |
| Global Pharmaceutical Company | Prostate cancer patient qualitative survey | Qualitative: 10 | F2F Interview | 2018/2019 |
| Global Pharmaceutical Company | Lung cancer patients quantitative survey | Quant: 100 | Web Survey | 2018/2019 |
Past and Current Studies (Patient Survey)
| Client | Research Theme | Survey Contents | Sample Size | Method | Date |
|---|---|---|---|---|---|
| Domestic Pharma | Quantitative Research of Ulcerative Colitis Patients | Quantitative survey on selection and acceptability of treatment methods for the patients with ulcerative colitis. | 300s | WEB Survey | 2018 |
| Global Pharma | Patient survey of OA (knee) · CLBP (low back pain) | Interview survey to grasp the Patient Journey Map as well as on intent to use drug during development. | 16s | Qualitative interview (IDI) | 2018 |
| Global Pharma | Quantitative survey of cancer patient | Quantitative survey on the actual condition and consultation of pain and anxiety for cancer patients and consultation partners. | 300s | WEB Survey | 2018-19 (Ongoing) |
| Global Pharma | Qualitative survey of Prostate cancer | Interview survey on communication with medical staff on fatigue / malaise during treatment. | 10s | Qualitative interview (Tel) | 2018-19 (Ongoing) |
| Global Pharma | Quantitative research of Lung Cancer Patients | Quantitative survey on IC contents, selection factors, IC satisfaction level etc. in drug selection of lung cancer patients | 100s | WEB Survey | 2018-19 (Ongoing) |
| Global Pharma | Acne Patients Survey | Quantitative Survey for concerning troubles and countermeasures for patients with mild acne (Reasons to visits / non-visits the hospital) | 300s | MROC | 2019 (Ongoing) |
| Domestic Pharma | Anaemia Patient Survey | Survey to grasp the benefits of new drugs vs current therapies targeting Anaemia patients | 50s | MROC | 2019 (Planned) |
| Domestic Pharma | Anaemia Patient Survey | Clinical CS survey for patients with Anaemia | Quant:100s Quality: 5s | WEB Survey (IDI) | 2019 (Planned) |
Patient Insights // OA/CLBP
Expert Analysis//
There was four main situation where pain put a great impact on work and in daily life. The most affected group was physical labour as well as nursing care service people who carry elderly people by a car or transporting the luggage through truck. The second is daily routine work such as getting up in the morning and going to washbasin with bended waist which put an affect in daily life. Next it was affecting in doing the housework, childcare, hobby and sports. Further, condition forced them to change their occupations as well as they were continuously feeling pain and fatigue in various actions on a daily basis, which was also resulting in anxiety of becoming impossible to walk in the future.Project Summary//
| 3H Support | In-Depth-Interview(Qualitative) |
| Timing of consultation | Pre Product Launch |
| Target | Knee OA, Back Pain CLBP |
| # of sample | n=12 (OA=6, CLBP=6) |
| Target Area | All Japan |
| Tactics | DB |
Impressive Number
4 Challenges. New drugs (Phase 3 completed: NDA under process) being developed by pharmaceutical company, this drug is based on new mechanism to prevent the pain. In order to make the launch successful in Japan, sponsor wanted to get some clue to construct the message for the patient through this interview. Are OA/CLBP Patients having any trouble in treatment currently. And if they have some problem then what is their issue. Whether this new drug can provide the solution of the problem of the patient or not. It was the target of this Interview.
Research Objective
・History of the intensity of pain from onset to the present
・In the history of treatment for the pain, what was the issue and what they wanted to have.
・Evaluating the concept of the new drugs
Patient Recruit
Phase III Trial//Alcohol Dependence
Expert Analysis//
Although this is a condition with many potential patients, we had no information regarding patient profile for those that visit hospitals (severe disease) and those that are our recruitment targets (mild ~ moderate disease). Therefore, we ran a pilot plan to test our hypothesis on a small scale, and used the result to characterize the second screening. The recruitment plan was modified twice during the recruitment period. Through strategical planning and optimization, we achieved 115% of the achievement target within 4 months.Project Summary//
| 3H Support | PatientRecruitment Advertisement Campaign |
| Timingof Consultation | Beforestart of study |
| Target | Heavy consumers |
| Numberof Sites | 80 |
| Area | Nationwide |
| MediaUsed | DB,Leaflets,Web |
Key Number// 2
Alcohol dependence is called the “disease of denial”, and it is difficult for patients to realize their disease and receive treatment. Patient eligibility was confirmed through the call center in two steps, the second step being a hearing held by qualified staff such as clinical psychologists (2ndscreening). This allowed us to successfully recruit for alcohol dependence, which was considered a very challenging project.Plan & Results//
| Plan | Results | |
| RecruitmentPeriod | 14months | 10 months |
| Numberof Referrals | 1,996 | 1,079 |
| NumberRandomized | 500 | 575 |
Phase III Trial//Overactive Bladder
Expert Analysis//
An example of successful site selection. The sites selected for this study were all very favorable for the referred patients in terms of location and time slots for visits. Especially 95% of the sites were within 10 minutes walking distance. The visit rate of referred patients was 76.6%, which is significantly higher than the average of 40~60%. Also, by being stringent with the selection criteria for referrals, less than the anticipated number of referrals were made, resulting in decreased burden for sites.
Project Summary//
| 3H Support | PatientRecruitment Advertisement Campaign |
| Timingof Consultation | Beforestart of study |
| Target | OABwet |
| Numberof Sites | 107 |
| Area | Nationwide |
| MediaUsed | DB,Leaflet,Web |
Key Number// 76.6
When the number of referrals are high, sites cannot handle contacts with the subjects in a timely manner, resulting in increased numbers of unresponsive patients or cancellations. The contact center helped with coordinating the first visit and passed on information about the patient onto sites, resulting in a high first visit rate after referral and an effective path to randomizations.Plan& Result//
| Plan | Results | |
| RecruitmentPeriod | 6 months | 6 months |
| Numberof Referrals | 1,579 | 684 |
| NumberRandomized | 500 | 473 |
Phase III Trial//Schizophrenia
Expert Analysis//
Follow-up with patients over the long span of 2 years to monitor changes in their disease state is something that could only have been done because of our volunteer database. By regularly following-up with patients, the communicator built a trust relationship with the patient. Because of this, the patient was willing to call us to and report changes in their disease symptoms, which made it possible for them to clear the difficult criteria of visiting the site during an acute exacerbation.
Project Summary//
| 3H Support | PatientRecruitment Advertisement Campaign |
| Timingof Consultation | Duringstudy |
| Target | Schizophrenia |
| Numberof Sites | 13 |
| Area | Nationwide |
| MediaUsed | DB、Web |
Key Number// 2
Schizophrenia has a bipolar nature which consists of “on” and “off” periods. This study’s targets were patients who were experiencing an acute episode of “on”. Because it was difficult to predict when patients would have an episode, we recruited patients who were stable and followed-up with them biweekly so that we would be able to catch them when they were close to having an episode and refer them. This was a strategy that required communication and trust between the communicator and schizophrenic patient.Plan& Result//
| Plan | Results | |
| RecruitmentPeriod | 27 months | 24 months |
| Numberof Referrals | – | 8 |
| NumberRandomized | 4 | 3 |
Oncology・Rare diseases
Patient Recruit Phase I~III Trial//Oncology –All Areas
Expert Analysis//
The website “Oncolo” was able to grow rapidly since its establishment because it includes the voices of patient advocacy groups and oncologists, and KOLs have acknowledged Oncolo’srecruitment approaches and objectives. Oncologains increased recognitions from front-line doctors daily, and some patients we recruit were actually referred to Oncolofrom their doctors. It became apparent that providing study information about rare cancers where treatment option information is scarce was an effective approach.Project Summary//
| 3H Support | PatientRecruitment Advertisement Campaign |
| Timingof Consultation | Beforestart of study～duringstudy |
| Target | Rarecancers, others |
| Numberof Sites | 1～15 |
| Area | Nationwide |
| MediaUsed | Oncolo |
Key Number// 100
Oncology is considered a difficult area for patient recruitment. At CROee, we strategically planned the contents of the Oncolowebsite to target patient recruitment in this area. After over 1 year of running the website and starting patient recruitment activities, we received especially good response from the rare cancer area. After 3 months of patient recruitment, over 100 people had responded to our recruitment, and some were even randomized within this short time frame.Plan & Results//
| Plan | Results | |
| RecruitmentPeriod | 6-12 months | Ongoing |
| Numberof Referrals | 4-10 | 10+ |
| NumberRandomized | 3-7 | Ongoing |
Patient Insight // Ongoing Cancer treatment patients
Expert Analysis//
●There are patients who can not consult their doctor about their pain and anxiety.●Patients usually get the care/treatment after consultation but there are the cases where care/treatment was not provided as well as even after receiving there was not improvement some said.
●So it is necessary to improve the current situation.
●After consultation 80% of patients were satisfied however solving the pain & anxiety was key points By communicating to doctor about their pain and anxiety to and getting the appropriate care which resulted in acceptance of longer duration of cancer treatment.
Project Summary //
| Sponsor | Global Pharma |
| Support from 3H | Quantitative Research |
| Timing of consultation | Considering Disease Awareness |
| Target | Ongoing treatment Cancer Patients |
| # of sample | n=287(BC,LC,CML,RCC) |
| Target area | All Japan |
| Medias used | Oncolo |
Impressive Number// 90
Japanese Cancer Patients were interviewed to know about their pain and their care giving condition whether it is sufficient or not.Those who felt uneasy even once was 89.9%, where most of them had an anxiety experience. In addition, 65.5% answered that they felt pain even once, and those who had pain during cancer treatments were over 60%.
There were more than half of patients who answered that “pain” and “anxiety” were affecting their cancer treatment. Further, half of total patient answered that they have consulted their doctors about pain where only 20% of patients replied that they have consulted to their doctors for anxiety. However 41.7% replied that they had not got care after consulted with doctor about their anxiety.
